Utilising a dangerous and untested method of time travel, a man from a post-apocalyptic future travels back to the present day on a mission to locate and eradicate the source of a deadly plague that will decimate the human race. But as he and virologist Dr. Cassandra Railly track the ‘Army of the Twelve Monkeys’ – the mysterious cult behind the outbreak, the effects of time travel threaten to destroy humanity’s last hope.