After a global viral pandemic wipes out over 80% of the world’s population, the 218-strong crew of a lone unaffected U.S. Navy Arleigh Burke-class guided missile destroyer, the fictional USS Nathan James (DDG-151), must try to find a cure, stop the virus and save humanity. Captain Eric Chandler, XO Slattery and the rest of the crew are working on disseminating the cure developed by paleomicrobiologist Dr. Rachel Scott. But as soon as they arrive back on U.S. soil they face new threats in the form of a new world order under the leadership of Granderson and a mysterious new enemy, the Immunes, bent on taking over the world.